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Effect of trabeculectomy with mitomycin C versus ologen implant in reducing intraocular pressure: A comparative study in patients with primary open-angle glaucoma

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Original Article

Author Details : Naresh Desinayak*, Pallavi Shree

Volume : 10, Issue : 3, Year : 2024

Article Page : 481-485

https://doi.org/10.18231/j.ijceo.2024.083

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Abstract

Aim and Objective: To compare the efficacy of mitomycin C (MMC) and Ologen implant (OLO) as adjuvants in Trabeculectomy in patients with POAG in eastern India.
Materials and Methods: It was a hospital based prospective randomized parallel group comparative study from November 2019 to April 2021. Forty eyes of forty patients of POAG with inadequate intraocular pressure (IOP) control were enrolled and randomly divided them into two groups of twenty. Group A (MMC) patients underwent MMC trabeculectomy, while Group B (OLO) patients underwent OLO trabeculectomy. All the cases were followed up post-operatively for six months, and the recorded IOP of each visit was analyses using software R 4.0.3 and R-studio.
Results: The preoperative IOP for the OLO group was 34.0 mmHg (IQR: 30.75 – 38.0), while for the MMC intervention group it was 36.50 mmHg (IQR: 31- 42). The difference in IOP between the two groups was insignificant (p= 0.24). On the first postoperative day, the IOP in the MMC group was 10.05 ± 3.65 mmHg and in the OLO group it was 10.35 ± 2.13 mmHg. Seven days after surgery, the mean IOP in MMC group was 9.45 ± 3.0 mmHg, while it was 11.50 ± 2.52 mmHg in the OLO group. One month after surgery, the mean IOP in the MMC group was 11.15 ± 4.25 mmHg, whereas it was 11.50±5.02 mmHg in OLO group. At 3 months postoperatively, the mean IOP in the MMC group was 12.25± 5.17 mmHg, while it was 12.70± 1.84 mmHg in the OLO group. Six months after surgery, the mean IOP in the MMC group was 10.50± 2.72 mmHg, whereas in the OLO group it was 13.35± 2.94 mmHg. In both the groups, there was significant reduction of IOP (p value < 0> Conclusion: In trabeculectomy surgery on POAG eyes, the MMC and OLO implants both successfully lower IOP. Between the two groups, there was no statistically significant difference in the success rate.
 

Keywords: Primary open angle glaucoma, Trabeculectomy, Mitomycin C, Ologen implant, Intraocular pressure.

How to cite : Desinayak N, Shree P, Effect of trabeculectomy with mitomycin C versus ologen implant in reducing intraocular pressure: A comparative study in patients with primary open-angle glaucoma. Indian J Clin Exp Ophthalmol 2024;10(3):481-485

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