- Visibility 26 Views
- Downloads 9 Downloads
- DOI 10.18231/j.ijceo.2021.010
-
CrossMark
Determinents of ocular alignment at 6 month after intermittent exotropia surgery
Introduction
Intermittent exotropia (IXT) is one of the most common types of exotropia in childhood. Based on distance-near deviation, intermittent exotropia are classified as basic, true divergence excess, pseudo-divergence excess and convergence insufficiency. The most common subtype of intermittent exotropia is basic type. It has various non-surgical treatment options such as occlusion therapy, orthoptic exercise and minus lenses, but the definitive treatment for intermittent exotropia is surgical correction.[1], [2], [3], [4] Bilateral lateral rectus recession (BLR-rec) and unilateral lateral rectus recession combined with medial rectus resection in the same eye (R&R) are the two most common procedures.
Many researchers[2], [5] have reported that surgery for intermittent exotropia is easy and attain satisfying results for surgeons and patients during the early postoperative period, but the surgical success rate decrease with time after the progress of an exotropic drift. After the surgical treatment the postoperative course in intermittent exotropia is variable during several early months. Most cases show an initial overcorrection and then a change to orthotropia or undercorrection according to the exogenic drift. Study by Ruttum[6] suggested unpredictability of the postoperative course in the terms of initial ocular alignment and the direction of early postoperative exogenic drift. These postoperative variations depending upon the preoperative factors like measure the target angle and postoperative factors like changes in wound healing process and convergence/ divergence tone of the muscles, so they considered that postoperative changes would stabilize in about six months and that surgical outcomes would be either early surgical failure (overcorrection and undercorrected exotropia) or surgical success (orthophoria/tropia).
In this study, we retrospectively reviewed the cases of intermittent exotropia who underwent bilateral LR recession and unilateral LR recession- MR resection and had a minimum follow-up of 6 months to evaluate the postoperative ocular alignment in immediate & long term after unilateral LR recession- MR resection bilateral LR recession (BLR) for intermittent exotropia.
Materials and Methods
This retrospective observational study was conducted in the department of Ophthalmology Chirayu medical college and Hospital Bhopal from April 2017 to March 2019 after clearance from ethical committee. 39 patients with intermittent exotropia (30-55PD) underwent surgery during this period. The inclusion criteria were:
Known case of intermittent exotropia and frequent phase of tropia during day.
Follow up at least 6 months.
Exclusion criteria
Presence of amblyopia
History of strabismus surgery
Presence of A or V pattern of nystagmus
Any type of ocular muscle paralysis or restrictive myopathy
Before surgery, all patients underwent full orthoptic examination. The target angle at the time of the operation was the distant exodeviation that was measured with the fixation target at 6 meter. To determine the target angle, forty five minutes occlusion was performed on the non dominant eye and an alternate prism bar cover test was done. Informed written consent was obtained from the patients; in case of small children consent was given by their Guardian. The procedure of surgery was explained in detail prior to surgery. In nineteen patients, lateral rectus muscle recession (maximum upto 10 mm) and medial rectus muscle resection (upto 6 mm) of one eye was done in non dominant eye and in bilateral Lateral Rectus Recession (Range 5.5-10 mm), based on prism bar cover test measurements determined with refractive correction, was performed. All surgeries were performed by same surgeon under local anaesthesia in adults whereas general anaesthesia was given to small children. Post-operatively, patients were examined on day 1, 1 month, 6 months and then last follow up. The alignments of eyes were checked with orthoptic examination (with and without correction of refractive state of the eye).
For the analysis of the final results, the deviation of 1st post-operative ocular alignment was compared with the 6th month ocular alignment. Surgical outcomes in reference of postoperative angle were compared & grouped as group A (esotropia >8-15 PD), group B (Orthophoria/tropia or esotropia/exotropia-8PD), & group C (exotropia>8-15PD). Success alignment was defined as orthotropia or esotropia/ exotropia within 6-8 PD.
Data was presented as mean, range and average. The variables were compared using t-test and Chi-square test. P -Value≤0.05 was considered significant. SPSS version software was used for Statistical analysis.
Results
|
Clinical characteristics |
N (%) |
|
Age at surgery (yrs) |
|
|
3-6 |
2 (6.7) |
|
7-10 |
6 (20) |
|
11-20 |
10 (33.3) |
|
20-30 |
12 (40) |
|
Gender |
|
|
Males |
11 (36.7) |
|
Females |
19 (63.3) |
|
Preoperative angles |
|
|
<30 PD |
8 (26.6) |
|
≥30 PD or <50 PD |
20 (66.7) |
|
≥50 PD |
2 (6.7) |
|
Surgical Procedure |
19 (63.3) |
|
Unilateral LR Rec-MR Res (R&R) B/L LR recession(BLR) |
11 (36.7) |
In our study maximum numbers of patients were operated at the age of 20-30 years (40%). Out of 30, nineteen of them were female and eleven were males, and their average age at their surgery was 16.6 (5-26) years. The follow-up time was 6-18 months (16.8months). The mean preoperative angle of the exotropia was 49.5 (30-55 PD). Among them, 19(63.3%) patients underwent unilateral R/R procedure and 11 (36.7%) patients underwent bilateral rectus recession.
|
Group (Postoperative angle of deviation) |
Number of patients on day 1 (%) |
Number of patients at 6 month (%) |
P Value |
|
Group A (Esotropia >8-15PD) |
3(10%) |
1(3.4%) |
0.16 |
|
Group B (Ortho or eso/exo within 8PD) |
22(73.3%) |
23 (76.6%) |
0.0001 |
|
Group C (Exotropia>8-15 PD) |
5 (16.7%) |
6 (20%) |
|
|
Surgical outcome at day 1(No) |
Surgical outcome at 6 month (No) |
|||||
|
|
BLR (11) |
R &R(19) |
Total |
BLR(11) |
R&R(19) |
Total |
|
Group A |
2 |
1 |
3 |
1 |
- |
1 |
|
Group B |
8 |
14 |
22 |
9 |
14 |
23 |
|
Group C |
1 |
4 |
5 |
1 |
5 |
6 |
Surgical outcome at post operative day 1 in group A, B & C were 10%, 73.3% and 16.7% respectively. Surgical outcome at 6months in group A, B & C were 3.4%, 76.6% & 20% respectively (p value <0.05 is significant). At 6 months success outcome in BLR was 81.8% & that in R/R was 73.6%.
In our study out of 30 patients, 2 patients from BLR group and 1 patient from R&R group were overcorrected post-operatively at day 1. Post-operatively at 6 months 1 patient from BLR group was overcorrected. In BLR group 8(72.7%) patients and RR group 14(73.6%) patients were orthophoric post-operatively at early alignment respectively. In R & R group 4 patients and 1 patient in BLR group was under corrected post-operatively at day 1. At 6 month follow up 9 (81.8%) patients in BLR and 14(73.6%) patients in RR group were orthophoric. In R&R group 5 patients and 1 patient in BLR group was under corrected post-operatively at 6 months.
Discussion
Surgical correction is considered the definitive treatment for deviations to restore the normal ocular alignment by either weakening (Recession) or strengthening (Resection) of extraocular muscles[7] Surgery is performed to achieve satisfactory and stable motor alignment to maintain proper binocular vision, amblyopia prevention and cosmetic betterment.[8]
As we discussed, surgical option is effective and definitive treatment in intermittent exotropia, but the long term results of surgical outcome remain variable and unpredictable. Multiple factors, such as age at surgery, surgical technique and preoperative deviation both distant and near, duration of deviation, presence of amblyopia and associated oblique dysfunction are factors affecting the final outcome. In addition, the importance of immediate postoperative alignment has been proved by numerous studies,[9], [10] although the best initial ocular alignment following surgery for exotropia remains controversial. This study is an attempt to find out whether there is any correlation between initial ocular alignment and long term success.
In the present study there was slight female predominance similar results were found in study by Gezer[11] where 58.2% patients were females.
In our study, Age range of the patients was 5 to 26 years (mean age 16.6 years). Mvogo et al.,[12] in his study showed the average age as 18.7 years ±11.2 that is comparable to present study.
The success outcome for orthophoria at day 1 and 6 months post-operatively were 73.3% and 76.6% respectively. The success rate at 6 months post-operatively was 60.4% in the study by Leow et al[8] whereas Ruttum[6] got success rate of 63% at 6 months respectively, both of which were inferior to our results. Causes of the difference between results may be age group, various methods of measuring deviation and surgical methods which affect the outcomes.
Park et al.[13] observed strong correlation between the alignments on the first postoperative day and at 6 months post-operatively (r = 0.7, P < .001). Leow et al.[8] also reported good correlation between week 1 and 6-month postoperative alignments (r = 0.5, P < .001). In our study, most of the cases achieved orthophoric (73.3%) at postoperative day 1. Out of 30, 3 patients overcorrected and 5 patients were under corrected at postoperative day 1. Success outcome at 6 months in our study, most of the cases were orthophoric (76.6%), one (3.4%) of the patient overcorrected and 20% were under corrected. Initially overcorrected 3 patients and 1 of 5 initially under corrected patients obtained orthophoria and 2 of 22 initially orthophoric patients were shifted to other groups at 6 months of follow-up. Overcorrected patients had more alignment changes as compared to initially under corrected and orthophoric patients. In the study by Leow et al. [8] similar results were found but guarantee of final good outcomes after 6 months of follow-up was not present. Most of initially orthophoric patients, 73.3% had no change of alignment up to 6 months of follow-up, so aiming orthophoria was recommended for all patients with intermittent exotropia undergoing surgical treatment.
Lee S et al.[14] reported a statistically significant relationship between the alignment at postoperative day 1 and at 1 year following both R&R and BLR surgery.
Choi et al.[15] concluded that initial overcorrection after intermittent exotropia surgery cannot predict long-term motor outcomes.
Rajavi et al.[16] suggested that early postoperative alignment of intermittent exotropia at 1 week can be considered a predictor of orthophoria at 6 months. Xie F et al.[17] reported that exogenic drift was more in the R&R group between day 1 and 6 weeks and from 6 to 12 months (P <0.05) and BLR group was associated with better long-term ocular alignment. Choi J et al.,[18] reported surgical outcomes were better in the BLR group than in the RR group at 6 months post-operatively. They also found that recurrence was more in the RR group than BLR group with time, as compared to our results as recurrence was more in the RR group.
The results of present study had some limitations. First, this was a retrospective study and is therefore subject to selection bias and types of surgical technique and another limitation is relatively low the number of patients in BLR and RR groups.
Conclusion
This study reports pre-operative deviation to be the strongest predictor for favorable outcome. Early ocular alignment of intermittent exotropia post-operatively at day 1 can be a determinant of orthophoria at 6 months. Orthophoric or slight overcorrection gives better ocular alignment but, prediction of long-term ocular alignment remains a grey zone.
Source of Funding
None.
Conflict of Interest
None.
References
- HM Burian, BE Spivey. The Surgical Management of Exodeviation. Trans Am Ophthalmol Soc 1964. [Google Scholar]
- VMB Fiorelli, M Goldchmit, CF Uesugui, C Souza-Dias. Intermittent exotropia: comparative surgical results of lateral recti-recession and monocular recess-resect. Arq Bras Oftalmol 2007. [Google Scholar] [Crossref]
- I Yadav, VP Singh, P Bhushan, RP Maurya, MK Singh. Comparison of surgical success rates and amount of corneal astigmatism induced by hag-back and conventional muscle recession surgery in horizontal strabismus. Indian J Clin Exp Ophthal 2015. [Google Scholar]
- M Roy, RP Maurya, VP Singh, MK Singh, S Loha, TB Singh. Comparision of incidence of oculocardiac reflex reflex between hang-back and conventional rectus recession in horizontal strabismus surgery. Indian J Clin Exp Ophthalmol 2020. [Google Scholar]
- AChia, L Seenyen, QB Long. Surgical Experiences With Two-Muscle Surgery for the Treatment of Intermittent Exotropia. J Am Assoc Pediatr Ophthalmol Strabismus 2006. [Google Scholar] [Crossref]
- MS Ruttum. Initial versus subsequent postoperative motor alignment in intermittent exotropia. J Am Assoc Pediatr Ophthalmol Strabismus 1997. [Google Scholar] [Crossref]
- GS Brum, RM Antunes-Foschini, CM Abbud, HE Bicas. Variations of postoperative ocular alignment in patients submitted to strabismus surgery. Oftalmol 2011. [Google Scholar]
- PL Leow, STC Ko, PKW Wu, CWN Chan. Exotropic Drift and Ocular Alignment After Surgical Correction for Intermittent Exotropia. J Pediatr Ophthalmol Strabismus 2010. [Google Scholar] [Crossref]
- JW Jeoung, MJ Lee, JM Hwang. Bilateral lateral rectus recession versus unilateral recess/resect procedure for exotropia with a dominant eye. Am J Ophthalmol 2006. [Google Scholar]
- JE Berland, ME Wilson, RA Saunders. Results of large (8–9 mm) bilateral lateral rectus recessions for exotropia. Binocular Vision Strabismus Q 1998. [Google Scholar]
- A Gezer, F Sezen, N Nasri, N Gözüm. Factors influencing the outcome of strabismus surgery in patients with exotropia. J Am Assoc Pediatr Ophthalmol Strabismus 2004. [Google Scholar] [Crossref]
- JM Richard, MM Parks. Intermittent exotropia: Surgical results in different age groups. Ophthalmology 1993. [Google Scholar]
- JS Park, JB Jeon, HY Choi. Relationship between surgical result and alignment on the day of surgery in intermittent exotropia. J Korean Ophthalmol Soc 2007. [Google Scholar]
- S Lee, YC Lee. Relationship between motor alignment at postoperative day 1 and at year 1 after symmetric and asymmetric surgery in intermittent exotropia. Jpn J Ophthalmol 2001. [Google Scholar]
- J Choi, SJ Kim, YS Yu. Initial postoperative deviation as a predic- tor of long-term outcome after surgery for intermittent exotropia. J AAPOS 2011. [Google Scholar]
- Z Rajavi, SF Hafezian, M Yaseri, K Sheibani. Early Postoperative Alignment as a Predictor of 6-Month Alignment After Intermittent Exotropia Surgery. J Pediatr Ophthalmol Strabismus 2014. [Google Scholar] [Crossref]
- F Xie, K Zhao, W Zhang. Comparison of surgical outcomes between bilateral recession and unilateral recession-resection in moderate-angle intermittent exotropia. J Am Assoc Pediatr Ophthalmol Strabismus 2019. [Google Scholar] [Crossref]
- J Choi, JW Chang, SJ Kim, YS Yu. The long-term survival analysis of bilateral lateral rectus recession versus unilateral recession-resection for intermittent exotropia. Am J Ophthalmol 2012. [Google Scholar]