- Visibility 79 Views
- Downloads 15 Downloads
Study of retinal nerve fiber layer and foveal thickness in amblyopia
- Author Details:
-
Shivam Sood
-
Amit Maitreya
-
Renu Dhasmana
Aim: To measure and compare the retinal nerve fiber layer (RNFL) and foveal thickness of normal and amblyopic eyes in unilateral amblyopia.
Material and Methods: This was a prospective, observational cross-sectional study conducted over a period of one year, after approval from the Institutional ethical committee. Children presenting to the pediatric ophthalmology clinic with a diagnosis of unilateral amblyopia due to anisometropia or strabismus or both were included. All children underwent clinical examination including BCVA, anterior and posterior segment examination and squint workup in cases of strabismus. Retinal nerve fiber layer (RNFL) and foveal thickness were measured in amblyopic as well as normal eye by Optovue RTvue 100 Fourier domain OCT.
Statistics: The Student t-test was used to compare the RNFL and foveal thickness in the normal and amblyopic eye.
Results: The study included 31 children out of which 16 (51.62%) were male and 15 (48.38%) female. Mean age of presentation was 11.29±3.06 years. There were 58.06% with anisometropic, 22.58% with strabismic and 19.36% subjects with mixed amblyopia. The mean foveal thickness of normal eyes was 254.64±35.57 ?m whereas that of corresponding fellow amblyopic eyes was 271.29±28.08 ?m with a p-value of 0.045. The mean RNFL was thicker in the normal eyes (111.06±17.63 ?m) than the fellow amblyopic eye (108.80±23.50 ?m) but this difference was not statistically significant (p=0.670).
Conclusion: Foveal thickness was found significantly more in the amblyopic eye than fellow normal eye whereas the RNFL thickness showed no statistically significant difference between the two groups.
Keywords: Retinal Nerve Fiber Layer, Foveal Thickness, Amblyopia, OCT
References
- Van Noorden GK, Campos EC. Binocular vision and ocular motility.6 th edition. Mosby: Philadelphia; 2002.
- Alotaibi AG, Al Enazi B. Unilateral amblyopia: Optical coherence tomography findings. Saudi J Ophthalmol. 2011 Oct; 25(4):405-9.
- Von Noorden GK, Middleditch PR. Histology of the monkey lateral geniculate nucleus after unilateral lid closure and experimental strabismus: further observations. Invest Ophthalmol Vis Sci. 1975;14(9):674–83.
- Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2224-30.
- Pang Y, Goodfellow GW, Allison C, Block S, Frantz KA. A prospective study of macular thickness in amblyopic children with unilateral high myopia. Invest Ophthalmol Vis Sci. 2011 Apr 14;52(5):2444-9.
- Al-Haddad CE, Mollayess GM, Cherfan CG, Jaafar DF, Bashshur ZF. Retinal nerve fibre layer and macular thickness in amblyopia as measured by spectral-domain optical coherence tomography. British Journal of Ophthalmology. 2011 Dec 1;95(12):1696-9.
- Wu SQ, Zhu LW, Xu QB, Xu JL, Zhang Y. Macular and peripapillary retinal nerve fiber layer thickness in children with hyperopic anisometropic amblyopia. International journal of ophthalmology. 2013;6(1):85.
- Andalib D, Javadzadeh A, Nabai R, Amizadeh Y. Macular and retinal nerve fiber layer thickness in unilateral anisometropic or strabismic amblyopia. Journal of Pediatric Ophthalmology & Strabismus. 2013;50(4):218-21.
- Dickmann A, Petroni S, Salerni A, Dell'Omo R, Balestrazzi E. Unilateral amblyopia: An optical coherence tomography study. J AAPOS. 2009 Apr;13(2):148-50.
- Atakan M, Çulfa S, Çalli U, Penbe AD, Atakan TG, Özertürk Y. Evaluation of Retinal Nerve Fiber Layer and Macular Thickness in Amblyopia. J Clin Exp Ophthalmol. 2015;6:437.
- Repka MX, Kraker RT, Tamkins SM, Suh DW, Sala NA, Beck RW et al. Retinal nerve fiber layer thickness in amblyopic eyes. Am J Ophthalmol. 2009 Jul;148(1):143-
- Yalcin E, Balci O. Peripapillary retinal nerve fiber layer and foveal thickness in hypermetropic anisometropic amblyopia. Clin Ophthalmol. 2014;8:749–753.
How to Cite This Article
Vancouver
Sood S, Maitreya A, Dhasmana R. Study of retinal nerve fiber layer and foveal thickness in amblyopia [Internet]. Indian J Clin Exp Ophthalmol. 2017 [cited 2025 Oct 31];3(1):66-68. Available from: https://doi.org/
APA
Sood, S., Maitreya, A., Dhasmana, R. (2017). Study of retinal nerve fiber layer and foveal thickness in amblyopia. Indian J Clin Exp Ophthalmol, 3(1), 66-68. https://doi.org/
MLA
Sood, Shivam, Maitreya, Amit, Dhasmana, Renu. "Study of retinal nerve fiber layer and foveal thickness in amblyopia." Indian J Clin Exp Ophthalmol, vol. 3, no. 1, 2017, pp. 66-68. https://doi.org/
Chicago
Sood, S., Maitreya, A., Dhasmana, R.. "Study of retinal nerve fiber layer and foveal thickness in amblyopia." Indian J Clin Exp Ophthalmol 3, no. 1 (2017): 66-68. https://doi.org/