- Visibility 189 Views
- Downloads 178 Downloads
- Permissions
- DOI 10.18231/j.ijceo.v.11.i.3.31
-
CrossMark
- Citation
Clinicopathological case series on ocular surface squamous neoplasia (OSSN) in a rural tertiary care centre
Ocular surface squamous neoplasia (OSSN) is a common malignancy globally, which affects the conjunctiva. It has a varied clinical spectrum and thus presents diagnostic and therapeutic challenges. This case series evaluates the clinical presentation, risk factors, diagnostic strategies, and management outcomes of OSSN. Four cases of histologically confirmed OSSN managed at a tertiary care hospital in North India (UPUMS, Saifai, Etawah) were taken. Data on patient demographics, clinical features, diagnostic techniques, treatment modalities, and follow-up outcomes were collected and analysed. Patients ranged from 40–70 years, with key risk factors including UV exposure. Clinical presentations varied from localised to diffuse conjunctival lesions. Treatment included topical chemotherapy and surgical excision. They were followed for a mean duration of 30.75 months without any recurrence. This case series highlights that OSSN can have a wide variety of clinical presentations and can sometimes mimic pterygium. Impression cytology is used to confirm the diagnosis (it reveals mild, moderate, or severe dysplasia of squamous cells). Treatment requires a tailored approach, including chemotherapy and the ‘no-touch technique’ of surgical excision, to manage neoplasia while preserving the patient’s vision and eye function as much as possible. Regular follow-up is needed to improve outcomes and decrease recurrence rates.
References
- Krishnaraj J, Das SS, Vendhan KE. Ocular surface squamous neoplasia (OSSN). IP Int J Ocul Oncol Oculoplasty. 2016;2():11– 22
- Yeoh CHY, Lee JJR, Lim BXH, Sundar G, Mehta JS, Chan ASY, et al. The management of ocular surface squamous neoplasia (OSSN). Int J Mol Sci. 2022;24(1):713.
- Hӧllhumer R, Williams S, Michelow P. Ocular surface squamous neoplasia: management and outcomes. Eye (Lond). 2021;35(6):1562–73.
- Gurnani B, Kaur K. Ocular Surface Squamous Neoplasia. 2023 Jul
- In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Shields CL, Shields JA. Tumors of the conjunctiva and cornea. Indian J Ophthalmol. 2019;67(12):1930–48.
- Gichuhi S, Macharia E, Kabiru J, Zindamoyen AM, Rono H, Ollando E, et al. Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study. Trop Med Int Health. 2016;21(12):1522–30.
- Dandala PP, Malladi P, Kavitha. Ocular surface squamous neoplasia (OSSN): a retrospective study. J Clin Diagn Res. 2015;9(11):NC10–
- Mishra DK, Taneja S, Singh V, Veena U, Kaliki S. Histopathological spectrum of ocular surface squamous neoplasia: a retrospective study of 776 lesions. Indian J Pathol Microbiol. 2022;65(1):3–7.
- Zaki AA, Farid SF. Management of intraepithelial and invasive neoplasia of the cornea and conjunctiva: a long-term follow up. Cornea. 2009;28(9):986–8.
- Moshtaghion SM, Abolhosseini M, Rezaei Kanavi M, Hosseini SB, Rezaei Kanavi M. Impression cytology for detection of clinically suspected ocular surface disorders: A cross-sectional study. Eur J Ophthalmol. 2021;31(3):943–50.
- Barros JD, Lowen MS, Moraes-Filho MN, Martins MC. Use of impression cytology for the detection of unsuspected ocular surface 562 Sharma et al. / Indian Journal of Clinical and Experimental Ophthalmology 2025;11(3):558–562 squamous neoplasia cells in pterygia. Arq Bras Oftalmol. 2014;77(5):305–9.
- Manoher JM, Praveena, Kochar A, Chauhan A. Topical 0.02% mitomycin C for management of primary corneal conjunctival intraepithelial neoplasia as primary therapy: a long term follow up. IAIM. 2016;3(8):16–22.
How to Cite This Article
Vancouver
Sharma R, Joshi D, Yadav N, Yadav V, Agarwal S. Clinicopathological case series on ocular surface squamous neoplasia (OSSN) in a rural tertiary care centre [Internet]. Indian J Clin Exp Ophthalmol. 2025 [cited 2025 Oct 02];11(3):558-562. Available from: https://doi.org/10.18231/j.ijceo.v.11.i.3.31
APA
Sharma, R., Joshi, D., Yadav, N., Yadav, V., Agarwal, S. (2025). Clinicopathological case series on ocular surface squamous neoplasia (OSSN) in a rural tertiary care centre . Indian J Clin Exp Ophthalmol, 11(3), 558-562. https://doi.org/10.18231/j.ijceo.v.11.i.3.31
MLA
Sharma, Reena, Joshi, Deepti, Yadav, Neha, Yadav, Vandana, Agarwal, Savita. "Clinicopathological case series on ocular surface squamous neoplasia (OSSN) in a rural tertiary care centre ." Indian J Clin Exp Ophthalmol, vol. 11, no. 3, 2025, pp. 558-562. https://doi.org/10.18231/j.ijceo.v.11.i.3.31
Chicago
Sharma, R., Joshi, D., Yadav, N., Yadav, V., Agarwal, S.. "Clinicopathological case series on ocular surface squamous neoplasia (OSSN) in a rural tertiary care centre ." Indian J Clin Exp Ophthalmol 11, no. 3 (2025): 558-562. https://doi.org/10.18231/j.ijceo.v.11.i.3.31