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- DOI 10.18231/j.ijceo.v.11.i.3.11
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CrossMark
A cross-sectional analytical study to assess the correlation of myopia with ganglion cell complex and retinal nerve fibre layer thickness
- Author Details:
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Ishwari Suhas Karve *
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Shubha Nagpal
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Deepa Muzumdar
Ishwari Suhas Karve *
Shubha Nagpal
Deepa Muzumdar
Purpose: To evaluate the correlation between retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness in varying grades of myopia and emmetropia, and assess their reliability as diagnostic markers for glaucoma in myopic individuals using optical coherence tomography (OCT).
Materials and Methods: This cross-sectional study, conducted at Bharati Vidyapeeth Medical College, Pune, India (November 2022–January 2024), included 148 eyes from 59 myopic patients and 15 emmetropic controls. Participants underwent comprehensive ophthalmological examinations, including OCT scans to measure RNFL and GCC thickness. Myopes were categorized by spherical equivalent (Group A1: <-3D, A2: -3 to -6D, A3: >-6D) and axial length (Group B1: <23mm, B2: 23–24mm, B3: >24mm). Statistical analyses included Paired-T tests, ANOVA, and Pearson correlation tests (P<0.05).
Results: Significant RNFL thinning was observed in myopes compared to emmetropes, particularly in the temporal quadrant for mild myopes and in nasal/inferior quadrants for moderate and severe myopes. RNFL thickness negatively correlated with increasing myopia and axial length (P<0.05). Conversely, GCC thickness remained stable across all myopia grades and axial lengths, showing no significant correlation with spherical equivalent or axial length.
Conclusion: RNFL was reduced in all grades of myopia and axial length. GCC was not affected. This study effectively concludes that GCC is more reliable marker than RNFL thickness to assess glaucoma in myopes.
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