The red reflex test: A simple tool to detect alarming pediatric eye disease

References

1. National Research Council (US) Committee on Disability Determination for Individuals with Visual Impairments; Lennie P, Van Hemel SB, editors. Visual impairments: determining eligibility for Social Security benefits. Washington (DC): National Academies Press (US); 2002. Chapter 4, Assessment of vision in infants and children [Internet]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK207548/
2. Brückner R. Exact strabismus diagnosis in 1/2- to 3-year-old children with a simple method, the 'transillumination test'. Ophthalmologica. 1962;144:184–98.
3. Tongue AC, Cibis GW. Brückner test. Ophthalmology. 1981;88(10):1041–4. doi:10.1016/s0161-6420(81)80034-6
   [Google Scholar]
4. Bowman R, Foster A. Testing the red reflex. Community Eye Health. 2018;31(101):23.
5. Nguyen M, Blair K. Red reflex. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
6. Kelly C, Anderson M, Smith H, Kousha O, Hitchcott N, Reddy MA, et al. Decolonising the 'red' reflex test: transitioning from terminology based on colour to anatomy. Eye (Lond). 2025;39(2):379–81.
7. Singh AD. Differential diagnosis of leukocoria. In: Berry JL, Damato BE, Singh AD., editors. Clinical Ophthalmic Oncology. Switzerland: Springer Nature; 2024. p. 11–27.
8. Sanchez I, Ortiz-Toquero S, Martin R, de Juan V. Advantages, limitations, and diagnostic accuracy of photoscreeners in early detection of amblyopia: a review. Clin Ophthalmol. 2016;10:1365–
9. Guidelines for universal eye screening in newborns [Internet]. New Delhi: National Health Mission; [cited 2025 Sep 10]. Available from: http://nhm.gov.in/images/pdf/programmes/RBSK/Resource_Docu ments/Revised_ROP_Guidelines-Web_Optimized.pdf
10. Saxena R, Sharma P, Pediatric Ophthalmology Expert Group. National consensus statement regarding pediatric eye examination, refraction, and amblyopia management. Indian J Ophthalmol. 2020;68(2):325–32.
11. Vempuluru VS, Kaliki S. Screening for Retinoblastoma: a systematic review of current strategies. Asia Pac J Ophthalmol (Phila). 2021;10(2):192–99.
12. Subhi Y, Schmidt DC, Al-Bakri M, Bach-Holm D, Kessel L. Diagnostic test accuracy of the red reflex test for ocular pathology in infants: a meta-analysis. JAMA Ophthalmol. 2021;139(1):33–40.
13. Mndeme FG, Mmbaga BT, Kim MJ, Sinke L, Allen L, Mgaya E, et al. Red reflex examination in reproductive and child health clinics for early detection of paediatric cataract and ocular media disorders: cross-sectional diagnostic accuracy and feasibility studies from Kilimanjaro, Tanzania. Eye (Lond). 2021;35(5):1347–53.
14. Abdolvahabi A, Taylor BW, Holden RL, Shaw EV, Kentsis A, Rodriguez-Galindo C, et al. Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma. PLoS One. 2013;8:e76677.
15. Munson MC, Plewman DL, Baumer KM, Henning R, Zahler CT, Kietzman AT, et al. Autonomous early detection of eye disease in childhood photographs. Sci Adv. 2019;5(10):eaax6363.