Should visual evoked potential be an essential protocol for amblyopia management? - A novel protocol

• Author Details:   
• Siddharth Khanna
• Naheed Akhtar ^*
• Mujahid Beg
• Uroos Izhar

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Background: Amblyopia is a neurodevelopmental visual disorder caused by abnormal visual input during early childhood, leading to impaired visual acuity. Visual evoked potentials (VEP) serve as an objective measure of visual pathway integrity, with P100 latency often prolonged in amblyopic eyes. Vitamin B12, crucial for neural function, has been implicated in optic neuropathies, though its association with amblyopia remains uncertain.

Aim: This study aims to explore the association between Visual evoked potentials (VEP) and Vitamin B12 levels in different types and grades of amblyopia among children in North India.

Materials and Methods: A cross-sectional study was conducted involving 45 children aged 6-16 years diagnosed with either strabismic or anisometropic amblyopia. VEP P100 latency and N75-P100 amplitude were measured using the VEP machine (Nicolet AT2+6 Amplifier). Vitamin B12 levels were estimated using chemiluminescence immunoassay (CLIA). Data were analysed using t-tests and ANOVA.

Results: VEP P100 latency was significantly prolonged, and N75-P100 amplitude was significantly reduced in amblyopic eyes compared to fellow eyes (p < 0>

Conclusion: VEP serves as an important diagnostic tool for detecting neurophysiological changes associated with amblyopia. Vitamin B12 levels may not significantly influence the condition's severity or type. Further research is needed to explore the role of nutritional factors in amblyopia.

Keywords: Amblyopia, Visual evoked potentials, Vitamin B12.