Clinical Features and OCT Imaging in Adult Vitelliform Macular Dystrophy: A Series of Three Cases.

Authors: Maheswari Kasilingam, Purnananda Mishra, Nithya Manoharan, Nanthene Rajmohan

DOI: 10.18231/j.ijceo.8871.1761819609

Keywords: Adult Vitelliform Macular Dystrophy ,OCT, BEST one gene

Abstract: Best Vitelliform Macular Dystrophy (BVMD) is indeed an autosomal dominant condition, primarily linked to mutations in the BEST1 gene, which encodes the bestrophin-1 protein. This protein plays a crucial role as a calcium-activated chloride channel in the retinal pigment epithelium (RPE), where it is involved in maintaining ion homeostasis and fluid regulation. However Adult Vitelliform Macular Dystrophy (AVMD) is rare .We report series of three cases of Adult Vitelliform Macular Dystrophy who presented in the Vitelliform stage. Optical coherence Tomography (OCT) shows hyper-reflective material accumulation below the fovea, and above the retinal pigment epithelium.