Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 4, Issue : 2, Year : 2018
Article Page : 182-188
https://doi.org/10.18231/2395-1451.2018.0041
Abstract
Introduction: Cognitive impairment may be present at birth or can occur later in adulthood. Few studies have shown correlation of cognition with retinal nerve fiber layer thickness (RNFL). The present study was planned to analyse RNFL thickness in disorders of cognition.
Materials and Methods: 60 eyes of cognitive impairment were included. All patients underwent RNFL thickness measurement by OCT at initial visit and after 3 months. Statistical analysis was done with a p value less than 0.05 to be significant.
Results: 60 eyes of cases of cognitive impairment were included. 16 (53%) cases had cognitive impairment following traumatic brain injury and 14 (47%) cases were secondary to Alzheimer’s disease. The mean RNFL thickness in the superior quadrant was 105.92 µm ±28.343µm at initial visit and at 3 months follow up was 105.72 µm±27.916 µm, in the nasal quadrant was 69.17 µm ± 13.199µm at initial visit and at 3 months follow up was 68.97 µm± 13.119 µm, in the inferior quadrant RNFL thickness was 111.03 µm±22.558 µmat initial visit and at 3 months follow up was 110.92 µm±22.372 µm, in the temporal quadrant was 59.35 µm ±11.333 µm at initial visit and at 3 months follow up was 59.18 µm ±11.247 µm but the difference was not statistically significant. Subgroup analysis of cases also did not show any statistically significant difference in RNFL thickness.
Conclusion: RNFL thickness remains unaffected in cognitive disorders. However studies on a large sample of patients with a longer follow up are needed.
Keywords: Cognitive impairment, RNFL thickness, Optical coherence tomography.
How to cite : Praveen Kumar K V, Gomase S N, Chiranjeevi P, Analysis of retinal nerve fiber layer thickness in cognitive impairment. Indian J Clin Exp Ophthalmol 2018;4(2):182-188
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
