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Comparative analysis of 0.4% vs 0.5% ketorolac tromethamine ophthalmic solution in post operative small incision cataract surgery patients

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Original Article

Author Details : Manmohan Bhanot, Preet Sood

Volume : 3, Issue : 3, Year : 2017

Article Page : 267-269

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Abstract

Purpose: The study was to compare the effectiveness and patient tolerability of two strengths of ketorolac tromethamine ophthalmic solution i.e. 0.4% vs 0.5% in post-operative small incision cataract surgery patients.
The study was conducted in Sri Guru Ram Dass institute of medical Sciences and research Amritsar.
Materials and Method: This is a randomized single blind investigator masked study. Total fifty patients (25 in each group) screened for cataract surgery were enrolled. The patients were randomized and either of study medication was used. Study medications were ketorolac 0.4% and ketorolac 0.5% eye drops. One drop of each drug was instilled in operative patient in each group thrice day. Thereafter, Slit-lamp examination was done for aqueous cell and flare. Intraocular pressure was checked. The patients were evaluated for subjective tolerance postoperatively at days 1, 3, 5 7, 15and 30. The results were compared between the groups, also with baseline.
Results: Only difference between two strength ketorolac is less stinging, discomfort and better ocular tolerability of ketorolac 0.4%. The patient operative outcome is same in the both strength. Ketorolac 0.4% has proven to better tolerated on the visual analogue scale. Ocular comfort was also much better. Although this difference is not statistically significant.
In other parameters, difference were not observed between the two groups for best-corrected visual acuity, IOP& slit-lamp assessment of cells and flare measured.
Conclusions: 0.4% ketorolac tromethamine ophthalmic solution is equally effective as 0.5% ketorolac tromethamine ophthalmic solution in reducing post cataract inflammation. But Patients with 0.4% ketorolac reported less discomfort.

Keywords: Ocular inflammation, Ketorolac, Ocular discomfort, Intraocular Pressure, Ocular pain, Visual analogue scale

How to cite : Bhanot M, Sood P, Comparative analysis of 0.4% vs 0.5% ketorolac tromethamine ophthalmic solution in post operative small incision cataract surgery patients. Indian J Clin Exp Ophthalmol 2017;3(3):267-269

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