Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 1, Issue : 1, Year : 2015
Article Page : 35-40
Abstract
Objective: To evaluate which factors influence maximum gain in best-corrected visual acuity after intravitreal injection of Bevacizumab as treatment for diffuse diabetic macular edema.
Methods: This was a prospective, interventional trial including 112 eyes of 100 participants. Visual outcomes measured by change in visual acuity (VA) score, proportion gaining ?15 letters, and change in central retinal thickness (CRT), presence of macular ischaemia, IS/OS integrity.
Results: Mean change in the VA score was 9.2 ± 2.3 SD letters with a total of 79 eyes gaining ?15 letters. Change in median CRT was 81.5 ????m. Younger age, higher baseline VA score, shorter duration of Diabetic Macular Edema (DME), absence of macular ischemia and an intact IS/OS junction were significantly associated with greater VA score improvement.
Conclusion: Pronounced macular edema and intact IS/OS junction may have a positive impact, and marked macular ischemia and a high preoperative best-corrected visual acuity may have a negative impact, on an increase in best-corrected visual acuity after intravitreal Bevacizumab injection in patients with diabetic macular edema.
Key Words: Bevacizumab, Diabetic macular edema, IS/OS junction, Macular ischaemia.
How to cite : Gupta S K, Yadav I, Deshmukh S, Maurya R P, Singh V P, PREDICTORS OF VISUAL RESPONSE TO INTRAVITREAL BEVACIZUMAB FOR TREATMENT OF DIABETIC MACULAR EDEMA. Indian J Clin Exp Ophthalmol 2015;1(1):35-40
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