Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 1, Issue : 1, Year : 2015
Article Page : 22-28
Abstract
Background: This study was undertaken to evaluate and compare the efficacy and safety of topical solutions of Cyclosporine and Fluorometholone in patients of vernal keratoconjunctivitis.
Settings and design: This was a prospective, double blind, comparative, interventional randomized controlled trial,
Material and methods: Patients of vernal kerato-conjunctivitis were included in the study after obtaining their informed consent.Each eye of one patient was prescribed either Cyclosporine eye drops or Fluorometholone eye drops. Patients’ vernal keratoconjunctivitis specific symptoms, signs and intraocular pressure were graded and measured repeatedly till 90th day.
Statistical analysis used: The intra-group and inter-group changes in symptoms and signs during the course of study were compared using repeat measure ANOVA test.
Results: Forty four subjects completed the study, with male preponderance. There was a progressive statistically significant reduction in the symptoms of itching, watering discharge and photophobia from day 7 till day 30 in both the groups.In Cyclosporine group there intra ocular pressure remained unaffected (P=0.17), but, in Fluorometholone group there was a significant increase in intra ocular pressure (P<0.0001). In the patients with mild disease, the improvement was similar in both the groups (P=0.486, Repeated measures ANOVA test).
Conclusions: In mild cases of vernal keratoconjunctivitis, topical Cyclosporine is equally effective as topical Fluorometholone, and Cyclosporine is safer as there is no rise in intra ocular pressure.
Key words: cyclosporine, Fluorometholone, intra ocular pressure, randomized controlled trial, vernal keratoconjunctivitis
How to cite : Gupta S K, Kumar A, Verma A, Agrawal S, Katiyar V, TREATMENT OF VERNAL KERATOCONJUNCTIVITIS: COMPARISON BETWEEN TOPICAL CYCLOSPORINE 0.05% AND FLUOROMETHOLONE 0.1% IN TERMS OF EFFICACY AND SAFETY. Indian J Clin Exp Ophthalmol 2015;1(1):22-28
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
