Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 2, Issue : 3, Year : 2016
Article Page : 263-265
Abstract
Introduction: To determine the rate of microbiological contamination in multi-use vials of bevacizumab used for multiple intravitreal injections and to determine the rate of endophthalmitis in patients who received intravitreal injections from these vials.
Methods: Eighteen 100-mg (4 mL) vials of bevacizumab (Avastin; F. Hoffmann-La Roche Ltd. Switzerland) were used for 327 intravitreal injections in period of 18 months. These vials were stored in refrigerator at 2 – 8oC for 30 days. From each vial, two samples of 0.05ml of avastin was withdrawn with the help of 1ml syringe at 7 and 30 days after the opening the vial. These samples were send for bacterial and fungal staining and culture. 327 patients who received intravitreal injections were monitored for signs and symptoms of inflammation or endopthalmitis.
Results: No evidence of microbiological contamination was detected in 18 vials sent for microbiological staining and culture. 327 patients who received intravitreal injections from these vials did not showed any signs or symptoms of inflammation or endopthalmitis.
Conclusions: Using the muti-use vials of bevacizumab for intravitreal injections which are stored for up to 30 days in refrigerator at 2–8oC is safe.
Keywords: Bevacizumab, Endopthalmitis, Microbiological contamination, Multi-use vial
How to cite : Agarwal A, Dixti N, Garg N, Godara R, Rate of microbiological contamination of multi-use vials of bevacizumab and risk of endopthalmitis. Indian J Clin Exp Ophthalmol 2016;2(3):263-265
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