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Genotype-specific patterns and clinical implications of ocular morbidity in sickle cell disease patients: insights from a tertiary healthcare center in India

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Original Article

Author Details : Ipsita Khuntia, Sharmistha Behera, Devi Aiswarya Das*, Jeneeta Baa, Pallavi Routray, Sasmita Misra

Volume : 10, Issue : 4, Year : 2024

Article Page : 650-654

https://doi.org/10.18231/j.ijceo.2024.114

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Abstract

Background: Sickle cell disease (SCD) is a prevalent genetic disorder marked by chronic hemolysis and vaso-occlusive events, leading to multiorgan complications, including significant ocular morbidity. This study aims to elucidate genotype-specific patterns and clinical implications of ocular morbidity in SCD patients at a tertiary healthcare center in western Odisha, India.
Materials and Methods: A cross-sectional study was conducted at Veer Surendra Sai Institute of Medical Sciences and Research (VSSIMSAR), Burla, Sambalpur, Odisha, from November 2018 to October 2020. A total of 103 SCD patients were enrolled using convenience sampling. Detailed ocular examinations, including visual acuity assessment, anterior segment evaluation, fundoscopy, and additional imaging, were performed. Data were analyzed using SPSS to identify genotype-specific patterns of ocular morbidity.
Results: Of the 103 patients, 60 had HbSS and 43 had HbSC genotype. The overall prevalence of ocular manifestations was 76.6%, with HbSC patients showing a slightly higher prevalence (81.4%) compared to HbSS patients (73.3%). Conjunctival corkscrew vessels were significantly more prevalent in HbSC patients (p=0.041). No significant differences were found between genotypes for other anterior segment signs or non-proliferative and proliferative fundus signs.
Conclusion: Our study reveals a high prevalence of ocular morbidity in SCD patients, with notable genotype-specific patterns. HbSC patients are more prone to certain ocular manifestations, underscoring the need for genotype-specific screening and management strategies. Early detection and targeted interventions can mitigate vision loss and improve patient outcomes.
 

Keywords: Sickle cell disease (SCD), Ocular morbidity, Genotype- specific patterns, HbSS genotype, Proliferative sickle retinopathy (PSR).

How to cite : Khuntia I, Behera S, Das D A, Baa J, Routray P, Misra S, Genotype-specific patterns and clinical implications of ocular morbidity in sickle cell disease patients: insights from a tertiary healthcare center in India. Indian J Clin Exp Ophthalmol 2024;10(4):650-654

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