Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 2, Issue : 2, Year : 2016
Article Page : 83-86
Abstract
Objectives: To compare the intraocular pressure lowering efficacy of 0.5% timolol maleate versus 0.0015% tafluprost in cases of primary open angle glaucoma and ocular hypertension.
Methods and Materials: This prospective, open, randomized, parallel group study was conducted in 80 newly diagnosed primary open angle glaucoma (POAG) and ocular hypertension (OHT) cases which were randomized into two groups (I and II) of 40 cases each and received 0.5% timolol maleate and 0.0015% tafluprost respectively. Efficacy of the drugs was calculated as mmHg lowering in mean IOP observed at the end of 3 months and the observations made in both groups were compared using appropriate statistical tools.
Results: IOP at the different time points assessed during the baseline visit ranged from 24.27 to 25.10 mmHg, with a mean of 24.60 mmHg in group I and 24.65 to 25.45 mmHg, with a mean of 25.04 mmHg in group II. IOP at various time points assessed after 12 weeks ranged from 18.12 to 18.60 mmHg, with a mean of 18.36 mmHg for group I and 16.52 to 17.47 mmHg, with a mean of 16.97 mmHg for group II. Mean diurnal IOP reduction with timolol and tafluprost was 6.24 mmHg (25.37%) and 8.07 mmHg (32.23%) respectively, with the difference being statistically significant.
Conclusions: There is significant difference in IOP lowering efficacy between the two groups with tafluprost consistently achieving greater reduction in IOP as compared to timolol.
Key-words: Glaucoma; IOP; Ocular hypertension; POAG; Tafluprost; Timolol
How to cite : Singh G, Kaur N, Bhagat A, Gupta A K, The comparison of intraocular pressure lowering efficacy of 0.5% timolol maleate versus 0.0015% tafluprost in cases of primary open angle glaucoma and ocular hypertension. Indian J Clin Exp Ophthalmol 2016;2(2):83-86
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
