Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 10, Issue : 3, Year : 2024
Article Page : 549-553
https://doi.org/10.18231/j.ijceo.2024.095
Abstract
Background: Pseudoexfoliation syndrome, also known as PEX 1, is a systemic micro fibrillopathy associated with ageing that is brought on by the gradual buildup of extracellular white and grey matter on various ocular and extra ocular structures. It is deposited in extra-ocular tissues such the heart, blood vessels, meninges, liver, and lungs. Numerous investigations have shown a connection between PEX and glaucoma. A person with PEX is typically thought to be at risk for acquiring glaucoma, and vice versa.
Atherosclerosis is facilitated by dyslipidemia, which is an increase in plasma cholesterol, triglycerides (TGs), or both, or a low HDL level. A potential risk factor for the progression of cardiovascular disease is dyslipidemia. Numerous investigations have discovered abnormal lipid profiles in pseudoexfoliation syndrome patients, including elevated levels of triglycerides, cholesterol, and LDL. Due to the straight association between lipid levels, atherosclerosis, and cardiovascular risk, patients with PEX are shown to be at an elevated risk of cardiovascular and cerebrovascular events.
Objective: To study the correlation between dyslipidemia and pseudoexfoliation syndrome in patients above 50 years of age and compare it with age matched controls.
Materials and Methods: This case control study was conducted from November 2020 to November 2022 at SKIMS Medical College and Hospital, Srinagar and included 150 patients with PEX above 50 years of age and compared with age matched controls.
Results: In this study mean total cholesterol among cases was 176.88±34.76 mg/dl versus 172.94±51.51 mg/dl in controls. P-value for total cholesterol was statistically insignificant (0.438). Mean triglyceride level among cases was 180.11±54.70 mg/dl while as mean triglyceride level among controls was 163.14±46.21 mg/dl and P-value was found to be statistically significant. Mean LDL level among cases was 104.57±32.80 mg/dl while as in controls mean was 82.70±27.60 mg/dl. P-value for LDL levels was found to be statistically significant. Mean HDL levels among cases was found to be 41.93±8.94 mg/dl while as in controls mean was 39.67±13.73 mg/dl. P-value for HDL levels was statistically insignificant (0.09). Mean VLDL levels among cases was found to be 25.34±19.52 mg/dl while as in controls mean was 27.66±14.36mg/dl. P-value for VLDL levels was statistically insignificant (0.242).
Conclusion: There is significant correlation between dyslipidemia and pseudoexfoliation syndrome in patients above 50 years of age.
Keywords: Pseudoexfoliation, Dyslipidemia, Glaucoma.
How to cite : Qazi A S, Bashir S A, Lone I A, Association between pseudoexfoliation syndrome and dyslipidemia: A case control study. Indian J Clin Exp Ophthalmol 2024;10(3):549-553
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