Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 10, Issue : 3, Year : 2024
Article Page : 454-458
https://doi.org/10.18231/j.ijceo.2024.078
Abstract
Background: VKC (Vernal keratoconjunctivitis) is a chronic, bilateral ocular inflammatory disorder that primarily impacts young patients. Management of VKC is challenging due to its complex immunological etiology and chronic inflammatory components.
Materials and Methods: This prospective, single-center, randomized study was executed at the Outpatient Department of Ophthalmology, SGT Medical College, Hospital and Research Institute (FMHS), Budhera, Gurugram, for a duration of 18 months. A total of 102 clinically diagnosed VKC patients, aged above 5 years, have been then randomly divided into 3 groups (34 each). Group A received fluorometholone (0.1%) eye drops, Group B received cyclosporine (0.1%) eye drops, and Group C received tacrolimus (0.03%) eye ointment. Patients were evaluated at days 0, 7, 14, 28, 35, and two weeks post-medication using the Clinical Scoring System by Bleik and Tabbara to assess TSSS (Total Subjective Symptom Score) and TOSS (Total Objective Ocular Sign Score).
Results: Most patients were between 6-10 years old, with over 78% being males. Group A showed significant symptom reduction from the first week (mean TSSS reduction from 2.29_0.46 to 0.21_0.41, p<0.0001), while Groups B and C showed significant improvements from the second week (Group B: mean TSSS reduction from 2.5_0.51 to 0.12_0.33, p<0.0001; Group C: mean TSSS reduction from 2.29_0.46 to 1.00_0.00, p<0.0001). Conjunctival hyperemia and tarsal papillae improvements were more pronounced in Group B as compared to Groups A & C. No ocular complications were found, except for dose-dependent irritation in Group C.
Conclusion: While fluorometholone (0.1%) eye drops provided early symptom relief, its effects were not sustained. Cyclosporine (0.1%) eye drops and tacrolimus (0.03%) eye ointment showed delayed but sustained efficacy, making them suitable for long-term treatment of moderate to severe VKC. Fluorometholone may be used initially alongside immunomodulators for rapid symptom relief, followed by tapering as immunomodulators take effect.
Keywords: Vernal keratoconjunctivitis, Tacrolimus, Cyclosporine, Fluorometholone, immunomodulators, Ocular inflammation, Chronic conjunctivitis
How to cite : Kashyap R, Gupta T, Maurya R P, Roy M, To study efficacy of tacrolimus (0.03%) eye ointment, cyclosporine (0.1%) eye drops and fluorometholone (0.1%) eye drops in vernal keratoconjunctivitis. Indian J Clin Exp Ophthalmol 2024;10(3):454-458
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