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Can retinal nerve fiber layer thickness be an indicator of amblyopia – Opening new horizons

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Original Article

Author Details : Rumana Aafreen, Naheed Akhtar*, Abdul Waris

Volume : 10, Issue : 2, Year : 2024

Article Page : 343-349

https://doi.org/10.18231/j.ijceo.2024.061

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Abstract

Aims: To study the RNFL thickness in amblyopia at Institute of Ophthalmology, JNMCH, AMU, Aligarh.
Design of Study: Prospective cross-sectional study.
Material and Methods: This study was conducted on 30 amblyopic children of age ranging between 6-16 years at Institute of Ophthalmology, Jawaharlal Nehru Medical College and Hospital, AMU, Aligarh after taking institutional ethical clearance and informed consent from parents of the patients. A brief clinical history was taken and detailed eye examination was done for visual acuity. Evaluation and quantification of strabismus was done. SD- OCT was performed after dilatation of pupil with 1% cyclomid eye drop on all enrolled children for evaluation of RNFL thickness and GCC thickness. RNFL thickness and GCC thickness of amblyopic eyes were compared with the fellow eyes.
Statistical Analysis: Data entry and analysis was done using paired t-test and p- values <0> Results: Out of 30 children23 were anisometropic amblyopic and 7 were mixed amblyopic. Average RNFL thickness was more in amblyopic eye as compared to fellow eye. This difference in RNFL thickness between the eyes remained statistically significant in an anisometropic amblyopic eyes (p<0 p=0.50). p=0.88,0.30).> Conclusion: Amblyopic eyes have more RNFL thickness than fellow eyes. Therefore, we conclude that amblyopia may involve retinal structure, also exploding the old age myth that only cortical changes are responsible.
 

Keywords: Retinal nerve fiber layer (RNFL), Ganglion cell complex (GCC), Spectral domain optical coherence tomography (SD- OCT)

How to cite : Aafreen R, Akhtar N, Waris A, Can retinal nerve fiber layer thickness be an indicator of amblyopia – Opening new horizons. Indian J Clin Exp Ophthalmol 2024;10(2):343-349

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