Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 10, Issue : 2, Year : 2024
Article Page : 256-260
https://doi.org/10.18231/j.ijceo.2024.046
Abstract
Background: Oxidative stress plays an important role in the pathogenesis of diabetic complications including diabetic retinopathy (DR) and diabetic nephropathy (DN) as suggested by experimental and clinical studies. The study aimed to measure as well as compare total antioxidant capacity (TAC) and malondialdehyde (MDA) levels in type 2 diabetic patients (T2DM) with diabetic retinopathy and diabetic nephropathy.
Materials and Methods: In this cross-sectional study we measured serum TAC, MDA, fasting plasma glucose (FPG), and HbA1c levels in 3 groups of T2DM patients with 110 cases in each group: 1st group without DR and/or DN, 2nd group with DN, and 3rd group with DR. This study was done in a tertiary care hospital from Dec 2019 to Dec 2022. Data was analyzed using version 20 of SPSS software.
Results: In DR patients, TAC levels were significantly lower (P=0.000), and FPG and HbA1c levels were significantly higher (P=0.003 & P=0.001 respectively) than in DM and DN patients. However, MDA did not show any significant difference in all groups. In the proliferative DR group, duration of diabetes, MDA levels, FPG levels, and HbA1c levels were significantly high (P=0.027, P=0.033, P=0.014 & P=0.000 respectively) and TAC levels were significantly low (P=0.033) as compared to non-proliferative DR group.
Conclusion: Weakening of the antioxidant defence system with increased oxidative stress in DM is associated with complications like DR and DN and also with the progression of DR to its vision-threatening proliferative stage.
Keywords: Oxidative stress, Type 2 diabetes mellitus, Diabetic retinopathy, Diabetic nephropathy, Total antioxidant capacity, Malondialdehyde.
How to cite : Pawar V S, Patil S R, Sontakke A V, Patil P S, Oxidative stress in diabetic retinopathy and diabetic nephropathy. Indian J Clin Exp Ophthalmol 2024;10(2):256-260
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