Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 10, Issue : 1, Year : 2024
Article Page : 160-163
https://doi.org/10.18231/j.ijceo.2024.028
Abstract
Aims and Objectives: The aim of this study was to determine the role of hyperhomocysteinemia in the progression of diabetic retinopathy and to determine the association of hyperhomocysteinemia with various grades of diabetic retinopathy.
Diabetic retinopathy is the most common ocular complication of Diabetes mellitus. Various studies have shown that mild elevations of homocysteine in plasma are associated with an increased risk of vaso-occlusive disease, thrombosis, and stroke.
Materials and Methods: A total of 97 patients who were diagnosed with diabetic retinopathy from October 2018 to September 2019 were included in our study. Written informed consent was taken from all the participants. Best corrected visual acuity (BCVA), anterior segment examination using slit lamp biomicroscopy examination(SLE), fundoscopy using indirect ophthalmoscope and using 90D lens on slit lamp was done in all patients. Serum homocysteine was assessed in all. The data was analysed using SPSS version 17.0. Results were expressed as mean, frequency and percentage.
Results: Out of 97 patients, mean serum homocysteine seen in mild non proliferative diabetic retinopathy, moderate non proliferative diabetic retinopathy, severe non proliferative diabetic retinopathy and proliferative diabetic retinopathy was 13.8 ± 0.33, 14.6 ± 0.44, 14.64 ± 0.41 and 15.78 ± 1.33 respectively.
Conclusion: In our study we found serum homocysteine levels was elevated in proliferative diabetic retinopathy when compared to non-proliferative diabetic retinopathy.
Keywords: Diabetes mellitus, Hyperhomocysteinemia, Proliferative diabetic retinopathy, Homocysteine, Endothelium.
How to cite : Pooja H V, Lakshmi M S, Role of hyperhomocysteinemia in the progression of diabetic retinopathy. Indian J Clin Exp Ophthalmol 2024;10(1):160-163
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