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Comparative efficacy of cyclosporine 0.1%, rebamipide 2%, and carboxymethylcellulose-cyclosporine 0.05% combination eye drops in the management of dry eye disease among the Indian population

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Original Article

Author Details : Khushboo Bansal, Abhinav Goyal*

Volume : 10, Issue : 1, Year : 2024

Article Page : 89-93

https://doi.org/10.18231/j.ijceo.2024.015

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Abstract

Purpose: This comparative research study aims to evaluate and compare the results of three different eye drop formulations of Cyclosporine 0.1%, Rebamipide 2%, and a combination of Carboxymethylcellulose & Cyclosporine 0.05%, in treating dry eye cases among the Indian population.
Materials and Methods: This investigation employed a randomized controlled trial design to assess the efficacy of three distinct eye drop formulations. A total of 120 patients diagnosed with dry eye disease participated in this study. Participants were assigned to one of three treatment groups: Group C (cyclosporine 0.1%), Group R (rebamipide 2%), or Group CC (combination of carboxymethylcellulose and cyclosporine 0.05%). Patients take prescribed medication for six weeks. Patients were evaluated at baseline for tear production time (TFBUT) at two weeks, four weeks, and six weeks, tear production score using the Schirmer test, and dry eye symptoms were assessed with the Ocular Surface Disease Index (OSDI). The collected data were analyzed using appropriate tests to compare the effectiveness of three eye drop formulations in treating dry eye in the Indian population.
Results: Disease improvement compared to baseline was seen in all groups based on scoring of Schirmer's score, OSDI score, and TBUT.
Conclusion: All three treatment groups demonstrated improvements in tear film stability, tear production, and a reduction in dry eye symptoms over the six-week treatment period. However, further research with larger sample sizes and longer treatment durations is needed to establish the long-term efficacy and compare the effectiveness of these treatments.
 

Keywords: Carboxymethylcellulose, Cyclosporine, OSDI, Rebamipide, Schirmer's, TBUT

How to cite : Bansal K, Goyal A, Comparative efficacy of cyclosporine 0.1%, rebamipide 2%, and carboxymethylcellulose-cyclosporine 0.05% combination eye drops in the management of dry eye disease among the Indian population. Indian J Clin Exp Ophthalmol 2024;10(1):89-93

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