Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 2, Issue : 1, Year : 2016
Article Page : 42-47
Abstract
Objectives: In this study, intravitreal injection of triamcinolone acetonide (TA) was compared with posterior subtenon injection of TA for treatment of diabetic macular edema (DME).
Materials and Methods: In this prospective, open, randomized, parallel group, comparative study, 60 patients of diabetic macular oedema visiting the Department of Ophthalmology, Govt. Medical College, Patiala were included. The patients fulfilling the inclusion criteria and having none of the exclusion criteria were enrolled in the study after obtaining written informed consent. Patients were then randomized into two groups (group I, II) and received intravitreal and posterior subtenon injection of triamcinolone acetonide, respectively. The comparison was based on change in best corrected visual acuity and macular thickness using optical coherence tomography (OCT). The results were subjected to statistical analysis and observations thus made in both groups were compared.
Results: With intravitreal TA, the mean pre-treatment CMT, mean post-treatment CMT and mean reduction in CMT were 395.53 ± 15.31 ?m, 221.2 ± 10.71 ?m and 174.33 ?m (44.08 %) while the mean pre-treatment VA, mean post-treatment VA and mean improvement in VA were 0.79 ± 0.16, 0.51 ± 0.15 and 0.28 (36.11 %) logMAR units. With posterior subtenon TA, the mean pre-treatment CMT, mean post-treatment CMT and mean reduction in CMT were 394.43 ± 15.03 ?m, 247.3 ± 11.82 ?m and 147.13 ?m (37.3 %) while the mean pre-treatment VA, mean post-treatment VA and mean improvement in VA were 0.81 ± 0.15, 0.58 ± 0.14 and 0.23 (28.24 %) logMAR units. The mean pre-treatment IOP, mean post-treatment IOP and mean rise in IOP with intravitreal TA were 16.67 ± 1.92 mm Hg, 18.87 ± 1.81 mm Hg and 2.2 mm Hg (13.19 %), whereas with posterior subtenon TA were 16.87 ± 1.85 mm Hg, 17.4 ± 1.59 mm Hg and 0.53 (3.14 %).
Conclusions: When used in diabetic macular edema, intravitreal triamcinolone acetonide is more effective than posterior subtenon triamcinolone acetonide in reducing the central macular thickness, although it produces a greater rise in IOP than PST.
Key-words: Central macular thickness, Diabetic macular edema, IOP, triamcinolone
How to cite : Kaur N, Singh G, Singh A, Singh R, Dogra S, Intravitreal versus posterior subtenon injection of triamcinolone acetonide in diabetic macular edema. Indian J Clin Exp Ophthalmol 2016;2(1):42-47
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