---

Correlation of serum D-dimer levels with stages of diabetic retinopathy and gycosylated hemoglobin levels

---

Original Article

Author Details : Kiran Shetty, Lakshmi K*, Sarita Lobo, Vivekanad U

Volume : 8, Issue : 2, Year : 2022

Article Page : 245-249

https://doi.org/10.18231/j.ijceo.2022.049

Suggest article by email

Get Permission

---

Abstract

Diabetic retinopathy is a disorder where the perfusion of the retina may be affected owing to the microvascular changes taking place in the retinal blood vessels due to hypergycemia. D-dimer level has been used as a biomarker of hypercoagulability and fibrinolytic activity since it is a product of fibrin degradation. D-dimer level (as a marker of coagulation cascade/fibrinolysis activation) assessment in type 1 and type 2 diabetics and its correlation with diabetic retinopathy stages have shown positive correlation. The findings in present study endorse the view that Elevated D dimer levels in severe forms of diabetic retinopathy. 26.9% patients with D dimer values more than 1000 have had severe NPDR to proliferative diabetic retinopathy, while 80% patients with normal values have shown to have no diabetic changes in fundus. Poor glycemic control (>6.5%) becomes a strong predictor for occurrence of severe form of diabetic retinopathy. 92.3% patients have shown the same. Hence, this study showed a positive correlation between increased blood sugar levels, elevated glyco Hb levels and severity of diabetic retinopathy. Hence, prompt understanding and treatment of hyperglycemia may prevent complications of diabetic retinopathy. The levels of Plasma D dimer is higher in type 2 diabetes mellitus complicated with microangiopathy. D-dimer is an important marker for thrombus formation hence may play an important role in the pathogenesis of diabetic microangiopathy. Prophlylactic anticoagulant therapy and strict diabetic control can help in halting the progression of diabetic retinopathy.
 

Keywords: Diabetic retinopathy, D Dimer, Glycosylated hemoglobin.

How to cite : Shetty K, Lakshmi K, Lobo S, Vivekanad U, Correlation of serum D-dimer levels with stages of diabetic retinopathy and gycosylated hemoglobin levels. Indian J Clin Exp Ophthalmol 2022;8(2):245-249

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.