Indian Journal of Clinical and Experimental Ophthalmology
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 1, Issue : 4, Year : 2015
Article Page : 223-227
Abstract
Objectives: The aim of this study was to compare the intraocular pressure lowering efficacy of timolol maleate with brinzolamide in cases of primary open angle glaucoma and ocular hypertension.
Methods and Materials: This prospective, open, randomized, parallel group, comparative study was conducted in patients coming to the Department Of Ophthalmology, Rajindra Hospital attached to Government Medical College, Patiala. 60 patients of POAG or ocular hypertension were selected. Patients were then randomized into two groups (group I, II) and received 0.5 % timolol maleate and 1% brinzolamide respectively. Effectiveness of the drugs was calculated in terms of mm Hg fall in mean intraocular pressure at the end of 3 months. The observations thus made in both groups were compared.
Results: In group I the mean pre-treatment IOP, mean post-treatment IOP and mean reduction in IOP were 24.30 ± 0.99, 18.53 ± 1.22 and 5.77 (23.74%) for peak measurements, and 24.50 ± 1.08, 18.80 ± 1.22 and 5.70 (23.27%) for trough measurements. In group II the mean pre-treatment IOP, mean post-treatment IOP and mean reduction in IOP were 24.33 ± 0.96, 19.43 ± 1.14 and 4.90 (20.14%) for peak measurements, and 24.57 ± 0.97, 19.73 ± 1.11 and 4.84 (19.69%) for trough measurements.
Conclusions: In conclusion, there was a statistically significant difference between the IOP lowering in the two groups with timolol maleate producing more reduction in IOP than brinzolamide.
Key-words: Brinzolamide; Glaucoma; lOP; Ocular hypertension; POAG; Timolol.
How to cite : Dogra S, Singh G, Gupta A K, Chalia D, Kaur N, The intraocular pressure lowering efficacy of 0.5% timolol maleate versus 1% brinzolamide in cases of primary open angle glaucoma and ocular hypertension. Indian J Clin Exp Ophthalmol 2015;1(4):223-227
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