Print ISSN: 2395-1443
Online ISSN: 2395-1451
CODEN : IJCEKF
Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...Original Article
Author Details :
Volume : 6, Issue : 3, Year : 2020
Article Page : 440-444
https://doi.org/10.18231/j.ijceo.2020.094
Abstract
Background: Vernal keratoconjunctivitis is a chronic, recurrent, bilateral inflammatory disease of cornea
and conjunctiva affecting young children. Various treatment modalities of VKC are topical mast cell
stabilizers, anti-histaminics, corticosteroids, and immunomodulators.
Aim and Objectives: This study compared the efficacy of bepotastine besilate 1.5% and loteprednol
etabonate 0.5% topical eye drops in subjects with allergic conjunctival disease.
Materials and Methods: The patients were re-examined after 1 week and 2 weeks. At each follow up
visit, best corrected visual acuity, anterior segment examination using slit lamp, tear film examination
(Schirmer’s test and tear film breakup time) and intraocular pressure were measured. Patients were scored
based on severity of signs and symptoms on day 1, 7 and 15.
Results: Itching, tearing, photophobia, upper tarsal papillae, limbus, keratitis and discharge score 1 and
2 for both eyes at day 1, 7 and 15 was significantly more among Bepotastine Besilate 1.5% compared
to Loteprednol Etabonate. The mean IOP for both eyes at day 1, 7 and 15 was significantly more among
Loteprednol Etabonate 0.5% compared to Bepotastine Besilate 1.5%.
Conclusion: This study demonstrated that LE was more efficacious than B.B in treating patients of VKC,
but the mean IOP was found to be more in patients on LE.
Keywords: Conjunctiva, Itching, Photophobia, Tearing, Vernal keratoconjunctivitis.
How to cite : Deep U , Chander A , Rastogi P S , Ansari M , Comparison of the efficacy and safety of bepotastine besilate 1.5% and loteprednol etabonate 0.5% ophthalmic solution in patients of vernal keratoconjunctivitis. Indian J Clin Exp Ophthalmol 2020;6(3):440-444
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