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Role of intravitreal dexamethasone implant in HIV associated macular edema: A retrospective clinical trial

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Original Article

Author Details : Kaushik Sadhukhan, Bivas Bala*

Volume : 6, Issue : 1, Year : 2020

Article Page : 129-132

https://doi.org/10.18231/j.ijceo.2020.028

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Abstract

Aim: To investigate the role of intravitreal sustained release dexamethasone implant in AIDS associated
macular edema.
Materials and Methods: This hospital based retrospective interventional study (nonrandomized) was
conducted in Malda Medical College, West Bengal, India from September2017 to august 2019 where
18 eyes of 18 patients with HIV were included. After proper history taking and required investigations,
intravitreal sustained release dexamethasone implant was injected to each patient in respective eye under
topical anaesthesia with strict aseptic measures and utmost care. Institutional clearance and written
informed consent from each patient were taken before the procedure. Best corrected visual acuity (BCVA)
and intraocular pressure (IOP) measurement and central macular thickness (CMT) evaluation by spectral
domain optical coherence tomography (SD-OCT) were performed at baseline and after 1 month, 3 months,
6 months of injection. The data obtained then were put for paired t test using SPSS software.
Results: All patients had shown improvement in terms of BCVA as well as reduction of central macular
thickness (CMT). 12 patients had increased IOP at first visit for which topical anti glaucoma drugs were
prescribed and on subsequent visits their IOP were under control.
Conclusion: Intravitreal sustained release dexamethasone implant is a good option to tackle macular edema
in HIV infected patients.

Keywords: Acquired immune deficiency syndrome, Best corrected visual acuity, Central macular thickness, Human immunodeficiency virus, Immune recovery uveitis, Intraocular pressure, Macular edema, Spectral domain optical coherence tomography.

How to cite : Sadhukhan K, Bala B, Role of intravitreal dexamethasone implant in HIV associated macular edema: A retrospective clinical trial. Indian J Clin Exp Ophthalmol 2020;6(1):129-132

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