Ocular Surface Disease Index (OSDI) Vs Standardized Patient Evaluation of Eye Dryness (SPEED) Questionnaire for Assessment of Patient reported Symptoms in Dry Eye Disease

• padmavathi Velusamy,  
• Sreelakshmi pallamreddy,*  
• sandhya chedella

Abstract

Background: Dry Eye Disease (DED) presents diagnostic challenges due to its multifactorial nature and variable symptoms. Patient-reported outcome (PRO) questionnaires like the Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness (SPEED) aid in assessing DED symptoms. However, their correlation with clinical tests, particularly among young adults, is underexplored. Methodology: This cross-sectional study was carried out among young adults aged 18-35 in a tertiary hospital setting. Participants underwent comprehensive eye examinations, administration of OSDI and SPEED questionnaires, and Objective clinical tests including Schirmer's test, Tear Film Breakup Time (TBUT), and Ocular Surface Staining. Data analysis included mean scores, correlation analyses, and receiver operating characteristic (ROC) curve analysis. Results: Out of 248 participants, OSDI mean score was 12.56 ± 12.86, with 62.1% scoring 0-12. SPEED mean score was 4.06 ± 3.70, with 50.8% scoring 1-4. Correlations between OSDI/SPEED and clinical tests were moderate, showing associations with TBUT, Schirmer's test, and Ocular Surface Staining. OSDI and SPEED scores revealed a positive correlation in the study (R=0.35; P=0.0001), indicating their reliability in assessing DED severity. Higher questionnaire scores correlated with lower TBUT values and higher Oxford Scores, reflecting more severe symptoms and ocular surface damage. Conclusion: The study underscores the utility of OSDI and SPEED questionnaires in evaluating DED severity, with both demonstrating reliability in clinical and research contexts. However, integrating subjective symptoms with clinical findings remains crucial.

Keywords

Dry eye disease, Patient-reported outcome questionnaires, Ocular Surface Disease Index, Standardized Patient Evaluation of Eye Dryness